Hearing loss in preterm infants Ear, Nose and Throat Other specified hearing loss
Conditions
Interventions
This is an observational study which will only involve saliva samples and access to medical notes. Children with hearing loss will be invited to participate by their audiological paediatrician
ex-preterm children with normal hearing will be invited by their neonatologist. Saliva samples will be taken from children in both groups for genetic analysis of m.1555A>G. Clinical data including inf
Sponsors
University College London - Institute of Child Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Cases: babies born at 31 weeks and 6 days gestational age or less with hearing loss, treated on a neonatal unit within Greater London between 01/01/2009 -? 31/12/2013 Controls: babies born at 31 weeks and 6 days gestational age or less with normal hearing, treated on a neonatal unit within Greater London between 01/01/2009 ?- 31/12/2013
Exclusion criteria
Exclusion criteria: Cases: no exclusion criteria Controls: missing data in medication records
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Gentamicin administration, measured using data from medical notes | — |
Primary
| Measure | Time frame |
|---|---|
| Prevalence of the m.1555A>G mutation, measured using saliva samples tested for the mutation by direct DNA sequencing | — |
Countries
United Kingdom
Outcome results
None listed