Cardiovascular disease, dementia, cancer Other
Conditions
Interventions
Record level electronic health data will be requested from NHS England and equivalent registries in Scotland & Wales. These records will be used to follow-up the original HPS2-THRIVE cohort for an ext
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants are all part of the original HPS2-THRIVE cohort (randomised between 2007 and 2010). They were between 50 and 80 years old when invited to participate. Participants had a history of one of the following: 1. History of myocardial infarction 2. Cerebrovascular atherosclerotic disease (history of presumed ischaemic stroke, transient ischaemic attack or carotid revascularisation) 3. Peripheral arterial disease (i.e. intermittent claudication or history of revascularisation) 4. Diabetes mellitus with any of the above or with other evidence of symptomatic coronary heart disease (i.e. stable or unstable angina, or a history of coronary revascularisation or acute coronary syndrome) For inclusion into the legacy cohort, participants had to be resident in the UK
Exclusion criteria
Exclusion criteria: 1. Participants who have opted out from having their data provided by NHS England 2. Participants who have read the privacy notice and have decided that they do not want their data used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first planned analyses will be based on at least 15 years’ follow-up from trial initiation with further analyses planned at approximately 5 yearly intervals based on on-going linkage to NHS records. Appropriate analysis methods will be used to compare the risk ratios for first occurrence post-randomisation of each outcome of interest (dementia, stroke, all major cardiovascular disorders, other vascular disease complications, myopathies, heart failure, renal impairment, other health and care outcomes and death) between both allocated treatment groups | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Contacts
Public ContactMichelle Nunn
Outcome results
None listed