Nordic trial of nasogastric tube use after operations for cancer in the gullet

Conditions

Nasogastric tube decompression after resection for esophageal cancer with gastric conduit reconstruction Surgery

Hedberg J, Kauppila J, Aahlin EK, Edholm D, Johnsen G, Johansson J, Lagergren P, Lindblad M, Lindberg F, Helminen O, Löfdahl P, Førland DT, Vikhammer M, de Heer P, Sundbom M, Szabo E, Åkesson O, Nilsson M, Nilsson A, Achiam M, Mala T.

2025-07-31

10.1016/j.lanepe.2025.101411

Randomized controlled trial of nasogastric tube use after esophagectomy: study protocol for the kinetic trial

Jakob Hedberg, Magnus Sundbom, David Edholm, Eirik Kjus Aahlin, Éva Szabó et al. (19 authors)

Diseases of the Esophagus2024-02-162 citations

10.1093/dote/doae010

257. DIFFERENCES IN PERIOPERATIVE STRATEGIES IN ESOPHAGEAL CANCER TREATMENT IN 13 NORDIC UNIVERSITY HOSPITALS CALL FOR HIGH-LEVEL EVIDENCE REGARDING THESE PRACTICES

Michael Patrick Achiam, Magnus Nilsson, Oscar Åkesson, Jan Johansson, David Edholm et al. (17 authors)

Diseases of the Esophagus2022-09-01

10.1093/dote/doac051.257

Interventions

Participants will be allocated to either the intervention or control group. Allocation provided by online randomization with stratification for center, sex, and neck anastomosis (y/n). Intervention: I

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Histopathologically confirmed esophageal or GEJ cancer in locally advanced stages (cT1a N+ or cT1b-4a any N; M0) and considered technically resectable by the local tumor board 2. Age =18 years 3. Planned for esophagectomy with gastric conduit reconstruction 4. Written informed consent

Exclusion criteria

Exclusion criteria: 1. No resection performed (reason specified) 2. Alternative reconstruction method used (Roux-limb/colonic interponate) 3. Surgeon choosing to leave NG-tube (reason specified) 4. No ability to understand the study in terms of risk and benefits (including language difficulties)

Design outcomes

Primary

Measure	Time frame
Incidence of an anastomotic leak measured using CT scan with peroral contrast at 7 days and data accrual in an eCRF by 6 weeks post-surgery	—

Secondary

Measure	Time frame
1. Incidence of pneumonia measured using data accrual in an eCRF by 6 weeks post-surgery 2. Overall complications measured using data accrual in an eCRF by 6 weeks post-surgery 3. Length of stay measured using data accrual in an eCRF by 6 weeks post-surgery 4. Health-related quality of life measured using structured interviews at discharge and 6 weeks post-surgery 5. Survival measured using review of survival information in relevant linked registries at 5 years 6. C-reactive protein (CRP) level measured using data accrual of CRP levels in the first 7 postoperative days in an eCRF by 6 weeks post-surgery	—

Measure

Time frame

1. Incidence of pneumonia measured using data accrual in an eCRF by 6 weeks post-surgery 2. Overall complications measured using data accrual in an eCRF by 6 weeks post-surgery 3. Length of stay measured using data accrual in an eCRF by 6 weeks post-surgery 4. Health-related quality of life measured using structured interviews at discharge and 6 weeks post-surgery 5. Survival measured using review of survival information in relevant linked registries at 5 years 6. C-reactive protein (CRP) level measured using data accrual of CRP levels in the first 7 postoperative days in an eCRF by 6 weeks post-surgery

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Countries

Denmark, Finland, Norway, Sweden

Outcome results

None listed