Depression, Treatment-resistant Mental and Behavioural Disorders Depression, Treatment-resistant
Conditions
Interventions
1. Antidepressant medication switched (intervention):
Patients randomised to the intervention arm will have an appointment booked with their GP within 48 hours of the baseline assessment. At this appo
Sponsors
King's College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Consenting patients aged 16 years or over with a score of 13 or more on the Hamilton Rating Scale for Depression (HAM-D), 9 or more on the Beck Depression Inventory and who have been compliant with a specific serotonin reuptake inhibitor at a standard dose for at least four weeks (as ascertained by self report questionnaire) will be invited to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Temporary registrations 2. Under 16 years 3. Currently receiving psychological therapies (cognitive behavioural therapy, problem solving therapy, interpersonal therapy) 4. Other psychotropic medications apart from benzodiazepines 5. Case note diagnosis of schizophrenia or bipolar affective disorder 6. Currently being treated for drug or alcohol dependence 7. Suicidal patients 8. Psychotic depression as evidenced by delusions and/or hallucinations 9. Patient treated by secondary psychiatric services 10. Non-English speaking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the feasibility of conducting a larger randomised controlled trial to examine clinical effectiveness of switching an antidepressant medication to another from a different antidepressant class in primary care patients with treatment-refractory depression. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Whether demographic variables, social adversity, life events, physical health and disability, are associated with outcome 2. Whether patient and doctor beliefs about depression and antidepressant medication are associated with outcome | — |
Countries
United Kingdom
Outcome results
None listed