Cervical ripening prior to induction of labour Pregnancy and Childbirth Induction of labour
Conditions
Interventions
Isosorbide mononitrate 40 mg (or placebo) given vaginally 48 hours, 32 hours and 16 hours prior to scheduled admission for induction of labour.
Sponsors
Greater Glasgow Health Board (North Glasgow University Hospitals Division) and The University of Glasgow (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Bishop score less than or equal to 6 2. Singleton pregnancy 3. Nulliparity 4. Gestation greater than or equal to 37 completed weeks 5. Willing to self administer vaginal tablets
Exclusion criteria
Exclusion criteria: Fetal compromise of sufficient severity such that daily fetal monitoring is scheduled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| i. Elapsed time interval from hospital admission to vaginal delivery (defined as the time from admission for inpatient induction or admission in labour to delivery) ii. Costs to the health service of induction of labour iii. Women?s experience of induction of labour | — |
Secondary
| Measure | Time frame |
|---|---|
| iv. Operative delivery rates v. Incidence of unscheduled admission for reasons other than labour commencing vi. Duration and frequency of neonatal admissions to special care vii. Incidence of adverse maternal and fetal outcomes such as uterine hypercontractility, postpartum haemorrhage (maternal outcomes) and meconium stained liquor, five minute Apgar of less than seven (fetal outcomes) viii. Length of labour ix. Oxytocin augmentation rates x. Epidural usage xi. Proportion with unfavourable cervix at 24 hours after admission xii. Requirement for additional inpatient cervical ripening agent | — |
Countries
United Kingdom
Outcome results
None listed