Early detection of lung cancer Cancer Malignant neoplasm of bronchus and lung
Conditions
Interventions
This is a prospective cohort study for the collection of blood for autoantibody, protein and nucleic acid biomarkers, and nasal epithelium for transcriptomic analysis from individuals attending for lu
Sponsors
University Hospital Southampton NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Individuals undergoing a Lung Health Check 2. Ability to understand the study requirements and provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Deemed medically unfit for sample collection 2. Contraindication for study procedures or sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured using blood and nasal swab samples for biomarker analysis and clinical data routinely collected for the Lung Health Check (TLHC) at a single visit/timepoint when the patient has their CT scan: 1. Calculation of lung cancer risk stratification efficacy of one or any combination of biomarkers independent from or in combination with existing risk models (LLP/PLCOm2012) 2. Calculation of the alteration in diagnostic accuracy by the addition of one or more biomarkers to low dose CT scanning | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured using blood and nasal swab samples for biomarker analysis and clinical data routinely collected for the Lung Health Check (TLHC) at a single visit/timepoint when the patient has their CT scan: 1. Cost-efficacy changes from the addition of one or more biomarkers to low dose CT scanning 2. Cost-benefit analysis of proposed optimised clinical algorithm | — |
Countries
England, United Kingdom
Contacts
Public ContactDarran Ball
Outcome results
None listed