A prospective, randomised, controlled evaluation of the effects of optimisation of cerebral oxygenation and depth of anaesthesia on postoperative cognitive functioning in older patients undergoing major orthopaedic and abdominal surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN39503939

Enrollment

250

Registered

2006-09-15

Start date

2006-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative cognitive decline (POCD) Surgery Post-operative cognitive decline (POCD)

Interventions

1. Bi-spectral index monitor (BIS): monitor of depth of anaesthesia 2. Somanetics invos cerebral oximeter (SICO): monitor of cerebral oxygen saturation 200 out of 250 participants will be patients un

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 65 years or over 2. Due to undergo major abdominal or orthopaedic surgery or a healthy relative of such a patient 3. Able to give informed consent 4. Fluency in English

Exclusion criteria

Exclusion criteria: 1. Mild cognitive impairment 2. Dementia 3. Physical disability which would interfere with cognitive interviewing (blindness, inability to write)

Design outcomes

Primary

Measure	Time frame
1. The Cambridge Assessment for Mental Disorders in the Elderly (section B)	—

Secondary

Measure	Time frame
1. The Bristol Activities of Daily Living Scale 2. The Cornell depression scale 3. The Quality of Life instrument (EQ-5D, EuroQolGroup) 4. Cognitive Drug Research Battery (choice reaction time, simple reaction time, digit vigilance reaction time, number vigilance, visual working memory) 5. Client Service Receipt Inventory 6. Confusion Assessment Method 7. Trail-making A and B 8. Stroop Test	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 26, 2026