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Cognitive training as a facilitated self-help intervention for depression: a Medical Research Council (MRC) experimental medicine trial

Cognitive training as a facilitated self-help intervention for depression: a randomised interventional single centre treatment trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN39455344
Enrollment
120
Registered
2010-03-31
Start date
2008-03-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Mental Health Research Network, Primary Care Research Network for England

Interventions

1. Cognitive training self-help in addition to treatment-as-usual 2. Relaxation training self-help in addition to treatment-as-usual 3. Treatment-as-usual The cognitive training facilitated self-help

Sponsors

University of Exeter (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older, either sex 2. Currently depressed patients, whether they are currently taking antidepressant medication or not

Exclusion criteria

Exclusion criteria: 1. Current co-morbid diagnosis or history of bipolar disorder, schizophrenia or other psychotic disorders 2. Current and clinically significant drug or alcohol dependence 3. Persistent anti-social behaviour 4. Persistent self-injury requiring clinical management/therapy 5. Learning disability (intelligence quotient [IQ] less than 70) 6. Organic brain damage 7. Current formal face-to-face psychotherapy/counselling (does not include computer-based cognitive behavioural therapy [CBT], psychoeducation, or bibliotherapy) 8. Unable to engage with facilitated self-help treatment for physical, practical or other reasons (e.g. unable to comprehend materials)

Design outcomes

Primary

MeasureTime frame
Hamilton Rating Scale for Depression - 17 item version (HRS-D). Timepoints were assessed at baseline pre-treatment, 2 months post-baseline assessment (post-treatment), after 3 months follow-up (i.e., after 5 months post-baseline) and after 6 months follow-up (i.e., 8 months post baseline assessment).

Secondary

MeasureTime frame
Depressive symptoms: the Beck Depression Inventory (BDI-II). Timepoints were assessed at baseline pre-treatment, 2 months post-baseline assessment (post-treatment), after 3 months follow-up (i.e., after 5 months post-baseline) and after 6 months follow-up (i.e., 8 months post baseline assessment).

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026