Prevention of kidney failure using N-acetylcystein and sodium bicarbonate in patients undergoing aortic aneurysm repair.

Impact of N-acetylcystein and sodium bicarbonate administration on the prevention of contrast media-induced nephropathy in endovascular aortic aneurysm repair. A prospective, randomised, placebo-controlled trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN39325111

Enrollment

Registered

2009-11-27

Start date

2009-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic surgery. Renal failure. Surgery

Interventions

Patients will be randomly allocated, according to a computer-generated list, to one of two groups: A. Group NB (N-acetylcystein plus sodium bicarbonate) B. Group S (N-acetylcystein plus Saline). 1.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients between 18 and 85 years old. 2. Patients undergoing an elective endovascular aortic repair surgery. 3. ASA I-IV inclusively (ASA: American Society of Anesthesiologists).

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. Patients who were exposed to contrast media in the last 14 days. 3. Patients presenting with acute renal failure on the day of surgery, as indicated by an increase of 25% or more in serum creatinine from baseline values. 4. History of kidney transplant. 5. Patients with terminal renal failure, treated with dialysis.

Design outcomes

Primary

Measure	Time frame
1. the incidence of post operative renal failure; 2. the incidence of post operative renal failure requiring dialysis in the first 30 days following surgery;	—

Secondary

Measure	Time frame
The 30-day mortality of patients who had such a surgery.	—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026