Upper gastrointestinal and colorectal cancer resection Cancer Malignant neoplasm of colon
Conditions
Interventions
A restricted intra- and post-operative fluid regime with the use of ephedrine instead of fluids once losses have been replaced in the event of hypotension as opposed to a standard regime of fluid repl
Sponsors
Norfolk and Norwich University Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All adult patients (both males and females) undergoing elective colorectal or upper gastrointestinal surgery (gastrectomies, oesophagectomies) cancer resection at the Norfolk and Norwich University Hospital NHS Foundation Trust 2. All patients will have epidurals for pain relief
Exclusion criteria
Exclusion criteria: 1. American Society of Anaesthesiologists (ASA) classification 4 - 5 2. Chronic renal failure defined as a creatinine greater than 140 µmol/L 3. Congestive cardiac failure defined as New York Heart Association (NYHA) class III - IV 4. Pregnancy 5. Diabetes mellitus (excluding diet controlled) 6. Planned post-operative ventilation on intensive treatment unit (ITU) 7. Contraindication to epidural 8. Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grade II complications and above up to 30 days post-surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. 30 day post-operative mortality 2. Length of hospital stay 3. Post-operative hypotensive episodes. Duration of follow-up: 5 days post-operatively. | — |
Countries
United Kingdom
Outcome results
None listed