Prevention of cardiovascular events in at-risk population Circulatory System Cardiovascular events
Conditions
Interventions
Current interventions as of 27/02/2014:
All participants will receive lifestyle counselling and leaflets on modifiable risk factors.
The baseline observations are: height, weight, BMI, total choleste
Sponsors
University of Dundee (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men and women aged 40 years and over
Exclusion criteria
Exclusion criteria: 1. Known atherosclerotic disease 2. Indication for statin therapy according to current clinical practice 3. Known primary muscle disease 4. Contraindication to statin 5. Any serious illness that may compromise the subjects safety or completion of study 6. Any illness which means that the subject is unable to give informed consent 7. Known alcohol abuse 8. Drinking more than two glasses of grapefruit juice per day 9. Pregnancy and not using reliable method of contraception
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 09/01/2014: 1. Ability of BNP level to predict future cardiovascular events 2. Ability of MRI-derived whole body atheroma burden to predict future cardiovascular events Previous secondary outcome measures: Validation of the magnetic resonance imaging (MRI) screening tool as a predictor of cardiovascular disease | — |
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measures as of 09/01/2014: Ability of increased left ventricular mass as detected by MRI scan to predict future cardiovascular events Previous primary outcome measures: Left ventricular mass at two years | — |
Countries
Scotland, United Kingdom
Outcome results
None listed