Chronic kidney disease Urological and Genital Diseases Chronic kidney disease
Conditions
Interventions
The study will comprise of two visits. The first visit will be a familiarisation visit. This will involve and incremental shuttle walk test to determine the speed at which the endurance shuttle walk t
Sponsors
University Hospitals of Leicester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Kidney patients of both genders aged 18 or over, with established chronic kidney disease including those on renal replacement therapy or with a transplant 2. Matched healthy controls
Exclusion criteria
Exclusion criteria: 1. Aged under 18 years 2. Pregnancy 3. Received kidney transplant less than 6 months prior to study entry 4. Any element of study assessment protocol considered by own clinician to be contraindicated due to physical impairment, co-morbidity or any other reason 5. Inability to give informed consent for any reason 6. Visual or hearing impairment or insufficient command of English to give informed consent or comply with the assessment protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples will be analysed for: 1. Markers of metabolism, cardiovascular risk, inflammation, oxidative stress, endothelial activation and immune function in plasma serum 2. Analysis of immune and inflammatory cell populations by flow cytometry 3. Expression of mRNA by RT-PCR These will be measured from blood samples taken pre exercise, 5-10 minutes post exercise and 60 minutes post exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Anthropometric measures (height, weight, hip circumference) 2. Body composition by bioelectrical impedance analysis 3. Cardiac bioreactance by NICOM (non-invasive cardiac output monitoring) 4. Time spent in leisure activities (Leisure Time Exercise Questionnaire) These measures will be made once during the familiarisation visit (Visit 1). Clinical information will be obtained from medical records . | — |
Countries
England, United Kingdom
Contacts
Public ContactAlice Smith
Outcome results
None listed