Cervix cancer Cancer Cervix
Conditions
Interventions
1. Arm A: Chemotherapy with methotrexate and cisplatinum repeated every 14 days for three cycles. Radiotherapy consisting of a course of external beam therapy followed by intracavity brachytherapy to
Sponsors
Cancer Research UK (CRUK) (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Histologically diagnosed squamous cell carcinoma of the cervix uteri 2. International Federation of Gynecology and Obstetrics (FIGO) stage III, IVa or bulky stage II 3. No evidence of extra pelvic spread 4. Aged <70 years 5. World Health Organisation (WHO) performance 0-2 6. Suitable for radical radiotherapy 7. Suitable for chemotherapy 8. Adequate haematological and renal function 9. No history of previous malignancy, excluding successfully treated squamous and basal cell carcinoma of skin or carcinoma in situ of the cervix 10. No previous chemotherapy or radiotherapy 11. No contraindications to treatment
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed