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PPhoCUs: Polypharmacy, Pharmacists and Clinical Uncertainty – Understanding how pharmacist decision making can be improved in the context of polypharmacy

PPhoCUs: Polypharmacy, Pharmacists and Clinical Uncertainty

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN38879473
Enrollment
100
Registered
2024-10-15
Start date
2024-09-30
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polypharmacy (10 or more medicines) Other

Interventions

Phase 1: Observational audio recordings of structured medication reviews between pharmacists and patients Phase 2: Semi-structured interviews with pharmacists Phase 3: Semi-Structured interviews with

Sponsors

University of Exeter
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For Pharmacists (in Phases 1 and 2): 1. Registered as a Pharmacist with the General Pharmaceutical Council 2. Employed in the primary care sector, based in either a general practice or primary care network setting 3. Currently delivering or able to deliver structured medication reviews For Patients (in Phases 1 and 3): 1. 18 years old or older 2. Prescribed 10 or more medications on repeat 3. Booked to have a structured medication review with a clinical pharmacist in primary care 4. Able to freely give informed consent

Exclusion criteria

Exclusion criteria: For Pharmacists: 1. Pharmacists working in secondary care or community pharmacy settings 2. Healthcare professionals who are not registered pharmacists 3. Pharmacists with no experience or ability to deliver SMRs For Patients: 1. Under 18 years of age 2. Patients who are unable to freely give consent or lack capacity 3. End of Life Care patients 4. Care Home Residents 5. Patients identified by the host research site as being unsuitable for participation by virtue of being acutely or significantly unwell, difficulties in communicating, safety issues (e.g. noted on patient records or have overtly declined to be contacted by the practice) or welfare issues

Design outcomes

Primary

MeasureTime frame
Perceptions and experiences of clinical uncertainty using audio recordings of naturalistic encounters where pharmacists review polypharmacy with patients in GP practice settings

Secondary

MeasureTime frame
1. Joint navigation of clinical uncertainty using audio recordings of naturalistic encounters where pharmacists review polypharmacy with patients in GP practice settings 2. Pharmacist perceptions of clinical uncertainty using qualitative interviews 3. Patient perceptions of pharmacist-delivered polypharmacy reviews, including shared decision making, using qualitative interviews

Countries

England, United Kingdom

Contacts

Public ContactTomazo Kallis
t.j.kallis@exeter.ac.uk+44 1392 661000

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026