Pre- versus post-dilution haemofiltration: a prospective randomised cross-over study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN38768865

Enrollment

Registered

2005-07-06

Start date

2000-12-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal failure Urological and Genital Diseases Renal failure

Interventions

Continuous venovenous haemofiltration, predilution versus postdilution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eight critically ill patients with an indication for renal replacement therapy

Exclusion criteria

Exclusion criteria: Recent bleeding, treatment with aspirin within one week before inclusion or with therapeutic doses of unfractionated or low molecular weight heparin within 12 hours before inclusion or results of routine coagulation tests such as protrombin time (PT) and activated partial thromboplastin time (APTT) exceeding twice the upper limit of normal

Design outcomes

Primary

Measure	Time frame
Extracorporeal circuit survival time	—

Secondary

Measure	Time frame
Platelet activation, thrombin generation, urea clearance	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026