Effects of physostigimine and modafinil post brain injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN38764966

Enrollment

Registered

2005-09-13

Start date

2004-01-02

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe head trauma, subarachnoid haemorrhage Injury, Occupational Diseases, Poisoning Other and unspecified injuries of head

Interventions

Patients are randomised to receive modafinil, physostigmine or placebo.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have suffered brain injury

Exclusion criteria

Exclusion criteria: Past history of psychiatric illness

Design outcomes

Primary

Measure	Time frame
Cognitive changes noted on neuropsychology testing	—

Secondary

Measure	Time frame
Benefits noted on chronic therapy	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026