Studying cerebrovascular health in relation to resistance exercise in young, healthy women Circulatory System
Conditions
Interventions
This is a randomized control trial that evaluates cerebral blood flow control during a ten-week resistance training intervention.
Participants will be randomized to either a heavy-lifting group (able
Sponsors
McMaster University
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Young, healthy females aged 18-35 years 2. Must be able to maintain a habitual diet and perform resistance exercise two times per week throughout the trial 3. Must be able to perform exercise twice weekly 4. Able to begin exercise (assessed by Get Active Questionnaire) 5. Understand the study procedures and sign this form providing informed consent to participate in the study
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Mild traumatic brain injury in the last year 3. Any history of severe traumatic brain injury 4. Cardiovascular conditions 5. Cerebrovascular conditions 6. Neurological conditions 7. Metabolic syndrome 8. History of syncope or light-headedness 9. History of migraines or chronic headache 10. Respiratory illnesses 11. Diabetes 12. Claustrophobia 13. Any current musculoskeletal injury that would make resistance exercise difficult or unsafe 14. History of psychosis 15. Eating disorders 16. Manic or bipolar disorder 17. Major psychiatric conditions 18. Dependence on alcohol or drugs within the past year 19. Use of medications known to affect protein metabolism, including: 19.1. Corticosteroids 19.2. Non-steroidal anti-inflammatory drugs (prescription or daily over-the-counter use) 19.3. Prescription-strength acne medications 20. Use of anabolic steroids or other banned performance-enhancing substances as outlined by the Canadian Center for Ethics in Sport
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral-pressure flow relationship measured using a continuous blood pressure finger cuff and a transcranial doppler ultrasound at weeks 1-10, 12 during the leg press set. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cerebrovascular reactivity measured using the Douglas bag at weeks 1-10, 12 2. Vascular characteristics (pulse wave velocity, distensibility, global cerebral blood flow, flow mediated dilation) using tonometers and Duplex ultrasound at week 0, 10, and 12. 3. Fatigue characteristics (questionnaires, rating of perceived exertion, lactic acid concentration) measured using questionnaires, verbal ratings, and Nova Biomedical Lactate Plus Meter at weeks 1-10, 12. | — |
Countries
Canada
Contacts
Public ContactVanessa Mizzi
Outcome results
None listed