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How sex hormones influence melatonin suppression by evening light in healthy adults

Influence of sex steroid hormones on melatonin suppression and retinal light sensitivity during evening light exposure in healthy adults

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN38686596
Enrollment
36
Registered
2026-01-18
Start date
2026-01-15
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Light-induced melatonin suppression

Interventions

This single-centre laboratory study uses a repeated-measures, within-subject design. Participants complete five evening laboratory sessions: one dim-light control session and four bright-light exposur

Sponsors

Max Planck Society
Lead Sponsor

Eligibility

Sex/Gender
All
Age
23 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Age 23–35 years 2. Good physical and mental health 3. Normal or corrected-to-normal visual acuity and normal colour vision 4. Regular sleep–wake behaviour 5. For naturally cycling participants: regular menstrual cycles (26–35 days) 6. For oral contraceptive users: stable intake of monophasic combined oral contraceptive for =6 months

Exclusion criteria

Exclusion criteria: 1. Chronic medical, hormonal, ocular, neurological or psychiatric disorders 2. Regular use of systemic medication (except anti-allergic medication) 3. Shift work or inter-time-zone travel in the last month 4. Extreme chronotype or excessive daytime sleepiness 5. Current or recent pregnancy or breastfeeding 6. Intake of exogenous hormones other than contraceptive hormones 7. Substance abuse, excessive alcohol consumption, or recreational drug use

Countries

Germany

Contacts

Public ContactCarolina Guidolin
carolina.guidolin@tuebingen.mpg.de+49 (0)7071 601 217

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026