Inflammatory bowel disease (IBD), including Crohn's disease (CD), ulcerative colitis (UC) Digestive System Crohn disease [regional enteritis], Ulcerative colitis
Conditions
Interventions
Baseline measurement (Spring 2021):
For adult patients, when they are hospitalized in The Third Xiangya Hospital, they will be asked if they are willing to take part in the program and
Sponsors
Third Xiangya Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients: 1. Patients with inflammatory bowel disease (including Crohn’s disease and ulcerative colitis) or suspected IBD patients in The Third Xiangya Hospital and Hunan Children's Hospital 2. Be willing to take part in this program and provide written informed consent (if children, the consents are signed by the guardians) 3. All ages Controls: 1. Healthy participants from the Health Management Center of The Third Xiangya Hospital and Hunan Children's Hospital 2. All ages
Exclusion criteria
Exclusion criteria: 1. Patients who are unable to cooperate with work due to mental or physical reasons 2. Healthy controls who have gastrointestinal diseases and symptoms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Multi-omics integrated analyses including blood metabolomics, fecal metabolomics, metagenomics, and metaproteomics, measured using the Illumina sequencing platform and liquid chromatograph-mass spectrometer (LC-MS) at baseline 2. Degree of disease activity measured by CDAI and Mayo score at baseline and follow-up (every 6 months for 3 years) 3. Degree of disease in endoscopy measured by UCEIS and CDEIS at baseline and follow-up (every 6 months for 3 years) 4. Degree of inflammation in vivo measured using hemoglobin, platelets, albumin, calprotectin and CRP tests at baseline and follow-up (every 6 months for 3 years) 5. Resistance to anti-TNFa measured by the concentration of antiantibody at follow-up (every 6 months for 3 years) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Genetic characteristics measured using whole gene sequencing at baseline 2. Environment factors measured using Algal toxins and heavy metals at baseline 3. Living habits and psychological factors measured using the Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder- 7 (GAD-7), and the Inflammatory Bowel Disease Questionnaire (IBDQ) at baseline and follow-up (every 6 months for 3 years) | — |
Countries
China
Outcome results
None listed