Topic: Cancer
Conditions
Interventions
Patients are randomised to either a control group or to receive a physical activity intervention.
Patients in the control group receive usual care which includes their regular check-ups in the UCLH
Sponsors
University College London
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Myeloma survivors, who are assigned to UCLH myeloma clinics 2. Stable disease for at least 6 weeks, off treatment or on maintenance or consolidation treatment 3. Ability to give informed consent 4. A good performance status (ECOG 02) 5. Clinically able to carry out an exercise training programme on a regular basis (assessed by initial screening) 6. Aged at least 18 years
Exclusion criteria
Exclusion criteria: 1. Spinal instability (as assessed on radiology in multidisciplinary team (MDT)) meetings 2. Those who have recently (within 4 weeks) had spinal or other surgery for pathological fractures 3. An abnormal resting ECG, where clinically indicated unexplained by further cardiological workup 4. At risk of pathological fracture (Mirel’s score, see Appendix 1 of Protocol) 5. Already participating in an exercise programme as part of a research study 6. Unstable angina 7. Musculoskeletal disease limiting mobility 8. Cognitive impairment that impedes ability to complete questionnaires
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue; Timepoint(s): baseline, 3, 6 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Anxiety and depression; Timepoint(s): baseline, 3, 6 and 12 months 2. Body mass and body composition; Timepoint(s): baseline, 3, 6 and 12 months 3. Diet; Timepoint(s): baseline, 3, 6 and 12 months 4. Exercise capacity and cardiorespiratory fitness; Timepoint(s): baseline, 3, 6 and 12 months 5. Haematology, biochemistry, bone health markers (basic ALP, osteocalcin); Timepoint(s): baseline, 3, 6 and 12 months 6. Muscle strength and endurance; Timepoint(s): baseline, 3, 6, 12 months 7. Physical activity; Timepoint(s): baseline, 3, 6 and 12 months 8. Resting blood pressure; Timepoint(s): baseline, 3, 6 and 12 months 9. Self-efficacy; Timepoint(s): baseline, 3, 6 and 12 months 10. Sleep quality; Timepoint(s): baseline, 3, 6 and 12 months 11. Well-being; Timepoint(s): baseline, 3, 6 and 12 months | — |
Countries
England, United Kingdom
Contacts
Public ContactMaggie Heinrich
Outcome results
None listed