How does breathing in extra oxygen during late pregnancy change fetal blood flow and can this be used to help babies with congenital heart defects?

Maternal hyperoxygenation in diagnostic fetal imaging

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN38470689

Enrollment

200

Registered

2020-04-01

Start date

2017-09-11

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other obstetric conditions, not elsewhere classified Pregnancy and Childbirth

Interventions

The researchers plan to recruit 200 mothers with either healthy pregnancies, or known congenital or placental abnormalities which have been identified in their routine 20-week anomaly scan for additio

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women with a pregnancy at 18 weeks or later at the time of scan 2. 18 years of age and over 3. Can read the information sheet and understand the purpose of the study and what it would entail

Exclusion criteria

Exclusion criteria: All groups 1. Maternal weight > 125kg 2. Maternal claustrophobia 3. Patients in the first trimester of pregnancy 4. Use of any of the following medication: adriamycine, bleomycine, actinomycine, menadion, chlorpromazine, thiordiazine, chloroquine 5. Severe maternal respiratory pathology 6. Unable to give informed consent 7. Contra-indication to MRI Healthy controls 8. Fetal growth restriction 9. Fetal congenital anomaly 10. Maternal placental insufficiency

Design outcomes

Primary

Measure	Time frame
Fetal blood flow in the third trimester of normal pregnancies and those associated with fetal or placental pathologies measured by Ultrasound and Magnetic Resonance Imaging at baseline and with additional temporary oxygen supplementation	—

Secondary

Measure	Time frame
1. Placental volume measured by Magnetic Resonance Imaging at scan timepoint 2. Fetal weight measured by Magnetic Resonance Imaging at scan timepoint 3. Brain tissue volumes measured by Magnetic Resonance Imaging at scan timepoint 4. Changes to placental oxygen environment of normal pregnancies and those associated with fetal or placental pathologies measured by blood oxygen level dependent magnetic resonance imaging at baseline and with additional temporary oxygen supplementation 5. Pregnancy demographic and biometric outcome data, including but not limited to congenital heart diagnosis at birth, gestational age at birth, birth weight, head circumference	—

Measure

Time frame

1. Placental volume measured by Magnetic Resonance Imaging at scan timepoint 2. Fetal weight measured by Magnetic Resonance Imaging at scan timepoint 3. Brain tissue volumes measured by Magnetic Resonance Imaging at scan timepoint 4. Changes to placental oxygen environment of normal pregnancies and those associated with fetal or placental pathologies measured by blood oxygen level dependent magnetic resonance imaging at baseline and with additional temporary oxygen supplementation 5. Pregnancy demographic and biometric outcome data, including but not limited to congenital heart diagnosis at birth, gestational age at birth, birth weight, head circumference

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026