Myocardial ischaemia-reperfusion injury Circulatory System Myocardial infarction
Conditions
Interventions
Two groups were formed following computerised randomisation. Twenty patients were given dextran-70 (6%) infusion (Macrodex, Pharmalink, Inc., Upplands Vasby, Sweden) (group A), whilst in the control g
Sponsors
European Society of Anesthesiologists (ESA) (Belgium)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: First time cardiac surgery on Cardiopulmonary Bypass (CPB) (Coronary Artery Bypass Graft [CABG] or aortic valve replacement)
Exclusion criteria
Exclusion criteria: 1. 'Redo' operation 2. Hepatic disease 3. Renal dysfunction 4. Immunological disease 5. Steroid treatment 5. Intake of aspirin or other cyclooxygenase-inhibitor within seven days prior to surgery 6. Known allergy to volume expanders used in the study None of the patients received volatile anaesthetics, steroids or aprotinin and haemofiltration were not used either. No shed mediastinal blood was retransfused during the post-operative period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We have investigated the inflammatory mediator response determing the plasma concentration of some inflammatory mediators (procalcitonin, C-reactive protein, interleukin 6, interleukin 6r, interleukin 8, interleukin 10, macrophage migration inhibitory factor, soluble endothelial leukocyte adhesion molecule-1, soluble intercellular adhesion molecule-1, vascular cell adhesion molecule-1) and those of the ischaemia-reperfusion (cardiac troponin-I) between the dextran treated and the control groups following cardiac surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiopulmonary bypass alters vasomotor regulation reducing the endothelium dependent relaxation. We have investigated the effect of dextran on the kinetics of the haemodynamic variables (heart rate, arterial blood pressure, cardiac index, stroke volume index, systemic vascular resistance index, intrathoracic blood volume index, extravascular lung water index). | — |
Countries
Hungary
Outcome results
None listed