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Rehabilitation of poor vision of neurological origin

Visual rehabilitation: brain plasticity or neuronal regeneration?

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN38035929
Enrollment
30
Registered
2012-02-27
Start date
2010-06-30
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low vision Ear, Nose and Throat Unspecified visual impairment (binocular)

Interventions

Patients who meet the criteria for inclusion and exclusion are intervened with occlusion of the normal or better eye and an intensive visual stimulation procedure for periods of 5 hours daily for 10

Sponsors

Neurological Institute of Colombia (Colombia)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age greater than or equal to 18 2. Isquemic optic neuropathy 3. Optic neuropathy by Multiple Sclerosis 4. Amblyopia secondary to strabismus 5. Traumatic optic neuropathy 6. At least one year of evolution of the previous conditions 7. Alteration of unilateral or bilateral visual acuity, defined as unilateral or bilateral visual acuity less than 20/60 8. In case of bilateral involvement, there should be an eye with better visual acuity, still below the 20/60 9. The visually impaired should have some stability over time, without clinical signs of improvement, even with the best possible optical correction or intervention 10. Clinical condition equivalent to a diagnosis of low vision

Exclusion criteria

Exclusion criteria: 1. Visual deficit bilaterally and in the same visual range 2. Optic Atrophy of nonspecific of uncertain origin 3. Optical refractive errors 4. Low vision of ophthalmic pathology: glaucoma, sequelae of retinopathy of prematurity, hypertensive retinopathy, diabetic retinopathy, cataract, retinitis pigmentosa and macular degeneration associated with age 5. Presence of tumor disease of the optic nerve 6. Intensive therapy with steroids in the last 6 months 7. Relapsed Acute optic neuritis type in the last 6 months 8. Lack of ability to understand instructions and adhere to intervention

Design outcomes

Primary

MeasureTime frame
Comparison of tests before and after intervention will permit the evalution of the results

Secondary

MeasureTime frame
Changes in activation of cortical visual areas by functional magnetic resonance

Countries

Colombia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026