Group B Streptococcus agalactiae in pregnant women Pregnancy and Childbirth
Conditions
Interventions
Women will be recruited from clinical areas which often require speculum examinations and swabs taken as part of the routine assessment in the Rosie Hospital, Cambridge (e.g. the Maternity Assessment
Sponsors
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Attending the Rosie Hospital, Cambridge, pregnant at any gestation, for an assessment which includes a vaginal examination and swabs taken 2. Aged 16 years old and over, and have the capacity to provide informed consent for themselves
Exclusion criteria
Exclusion criteria: Not meeting the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence of Group B Streptococcus (GBS) in the maternal genital tract (positive/ negative) at the time of a clinically-indicated vaginal swab at any point in pregnancy, measured with the following methodologies: 1.Routine microbiological culture and sensitivity without enriched media 2.Enriched microbiological culture specific for GBS 3.DNA extraction for multiplex PCR, with two approaches: 3.1.qPCR for sip, a GBS-specific gene of which GBS has only one copy 3.2.Nested PCR-qPCR for a GBS-specific sequence of the 16S RNA gene, of which the genome has seven copies | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal and neonatal outcomes measured by examination of electronic medical records at the time of hospital discharge following delivery: 1. Mode of delivery 2. Complications with labour/delivery (e.g. fever, chorioamnionitis, intensive care admission) 3. Gestation at delivery (days) 4. Birthweight (kg) 5. Admission to the NICU (and indication for admission) 6. Stillbirth/neonatal death | — |
Countries
England, United Kingdom
Contacts
Public ContactEleanor Richards
Outcome results
None listed