Hormonal profiles modification, lower hunger scores, better anthropometric outcomes and reduced risk factors of the metabolic syndrome following a weight loss diet with carbohydrates eaten only at dinner

A randomised clinical trial examining leptin, ghrelin and adiponectin diurnal profiles modifications, hunger and satiety scores, anthropometric, biochemical and inflammation parameters following a weight loss diet with carbohydrates eaten only at dinner.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37829376

Enrollment

Registered

2009-12-03

Start date

2006-05-22

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

100 officers enrolled to a randomised single centre controlled interventional diet study. 78 Individuals met study criteria and were randomly allocated to the experimental/control groups. A standard

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Police officers from the Israeli Police Force (men and women) 2. Age 25-55 3. BMI >30

Exclusion criteria

Exclusion criteria: 1. Cardiovascular diseases 2. Hypertension 3. Diabetes mellitus or other primary diseases 4. Followed any type of diet regime within a year prior to the study 5. Pregnancy

Design outcomes

Primary

Measure	Time frame
1. Leptin, ghrelin (total) and adiponectin (High Molecular Weight) (Linco research sandwich ELISA kits) 2. Insulin (Abbot Microparticle Enzyme Immunoassay test kits) 3. Hunger-Satiety Score (H-SSc) a scale of descriptions from hunger to satiety (1= starving, 10= devastatingly full). 4. Glucose (Olympus enzymatic UV test kits) 5. Insulin resistance (Homeostasis Model Assesment) 6. Cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides (Olympus enzymatic colour test kits) 7. C-reactive protein (CRP) (Olympus Immunoturbidimetric test kits) 8. TNF-a (Human Serum [HS]) and IL-6 (HS) (R&D systems sandwich ELISA kits)	—

Measure

Time frame

1. Leptin, ghrelin (total) and adiponectin (High Molecular Weight) (Linco research sandwich ELISA kits) 2. Insulin (Abbot Microparticle Enzyme Immunoassay test kits) 3. Hunger-Satiety Score (H-SSc) a scale of descriptions from hunger to satiety (1= starving, 10= devastatingly full). 4. Glucose (Olympus enzymatic UV test kits) 5. Insulin resistance (Homeostasis Model Assesment) 6. Cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides (Olympus enzymatic colour test kits) 7. C-reactive protein (CRP) (Olympus Immunoturbidimetric test kits) 8. TNF-a (Human Serum [HS]) and IL-6 (HS) (R&D systems sandwich ELISA kits)

—

Secondary

Measure	Time frame
1. Weight, abdominal circumference, and percentage of body fat were measured regularly and on day o, 7, 90,180. 2. "Urge to eat" and "preoccupation with thoughts about food".	—

Countries

Israel

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 25, 2026