Dialysis-induced myocardial stunning Surgery Myocardial stunning
Conditions
Interventions
Each patient undergoes one week (three dialysis treatments) of standard haemodialysis, and one week (three dialysis treatments) of standard haemodialysis with supplemental oxygen to breathe
the chronological order of the two weeks is allocated by randomisation. Patients thereby act as their own controls. Monitored visits occur on the third treatment of each week. There is no further foll
Sponsors
Derby Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 18 years old, either sex 2. Chronic haemodialysis greater than 3 months
Exclusion criteria
Exclusion criteria: 1. New York Heart Association (NYHA) grade IV heart failure 2. Cardiac transplant 3. Known disorder of magnesium metabolism 4. Magnesium supplementation 5. Recent arrhythmia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of regional wall motion abnormalities. Key observations are taken pre-dialysis (baseline), 15 minutes prior to end of dialysis (peak stress) by cardiac echocardiography (for later offline semi-automated analysis for regional wall motion abnormalities). | — |
Secondary
| Measure | Time frame |
|---|---|
| Haemodynamic variables observed pre-dialysis, and throughout dialysis treatment, with continuous non-invasive measurement by finometer, and NICOM (bioreactance). | — |
Countries
United Kingdom
Outcome results
None listed