Digital breast tomosynthesis in screening younger higher risk women

A randomised trial of screening with digital breast tomosynthesis plus conventional digital 2D mammography versus 2D mammography alone in women aged 40 to 49 at increased risk of breast cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37806452

Enrollment

2904

Registered

2014-04-03

Start date

2014-04-01

Completion date

Unknown

Last updated

2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Cancer

Interventions

Participants who have not had a screening mammogram before will have a standard 2D mammogram and DBT. Women who have undergone screening mammography prior to entering the trial will b

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women aged 40 to 49 years inclusive with an increased risk of breast cancer by virtue of their family history and who have been referred for screening by a family history or genetics service. (Note some women will be aged 50 when they have their second screen within the study) Target Gender: Female; Upper Age Limit 50 years ; Lower Age Limit 40 years

Exclusion criteria

Exclusion criteria: 1. Inability to give informed consent, including inability to understand the nature and purpose of the study 2. Breast implants 3. Pregnancy 4. Previous breast cancer

Design outcomes

Primary

Measure	Time frame
Recall to assessment rate; Timepoint(s): At screening	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026