Wnt signalling in colon cancer

Is the tumour suppressor adenomatous polyposis coli (APC) crucial to iron mediated colorectal carcinogenesis? A single centre observational clinical laboratory study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN37721571

Enrollment

Registered

2011-02-24

Start date

2010-11-01

Completion date

Unknown

Last updated

2018-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: National Cancer Research Network

Interventions

This will include the collection of tissue from normal colonic tissue, adenomatous polyps and colorectal cancers. Alongside this we will collect serum and urine to measure systemic iron transport prot

Study Entry : Registration only

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged between 60 - 75 years, either sex 2. Bowel cancer screening patients attending for colonoscopy

Exclusion criteria

Exclusion criteria: 1. Unfit for colonoscopy 2. Previous colorectal cancer 3. Ongoing or previous cancer treatment (chemo-radiotherapy)

Design outcomes

Primary

Measure	Time frame
Measured at baseline, using the expression of proteins in the tissue and serum to detect the cellular and systemic iron transport proteins. The techniques used will include mass spectrometry, western blotting, real time PCR and immunohistochemistry.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026