The effect of antihypertensive treatment with Lisinopril and Labetalol on baroreflex sensitivity in stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37578410

Enrollment

Registered

2005-12-19

Start date

2005-01-07

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular: Stroke Circulatory System Stroke

Interventions

Our hypothesis is that treatment with the antihypertensive agents lisinopril and labetalol produces an improvement in baroreflex sensitivity in stroke patients. All patients seen on the rapid access

Eligibility

Inclusion criteria

Inclusion criteria: Patients with previous stroke or transient ischaemic attack (TIA). 1. Age > 18 years 2. Clinical diagnosis of stroke > 8 weeks ago 3. Stable neurology 4. Clinical indication for antihypertensive treatment 5. Informed consent

Exclusion criteria

Exclusion criteria: 1. Excessive ectopic activity 2. Atrial fibrillation 3. Contraindication to beta blocker therapy 4. Contraindication to ace inhibitor therapy 5. Clinical indication for treatment with ace inhibitor, beta blocker or angiotesin II antagonist other than hypertension 6. Conditions independently associated with autoimmune dysfunction (acute myocardial infarction, unstable angina, active heart failure, diabetes mellitus)

Design outcomes

Primary

Measure	Time frame
Change in BRS seen as a result of treatment with lisinopril and labetalol.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026