The effects of Modafinil on functional magnetic resonance imaging (fMRI) brain activation and functional performance during visual stimulation and visually guided tracking manoeuvres after sleep deprivation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37562266

Enrollment

Registered

2005-04-13

Start date

2004-08-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N/A Nervous System Diseases Sleep disorders

Interventions

Please note that as of 16/09/09 the status of this trial has been changed to "Stopped" due to relocation of primary investigator (PI) and lack of funding. Each subject will be scanned 3 times, the f

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 30 Healthy volunteers between the ages of 18-65

Exclusion criteria

Exclusion criteria: Previous neurological disease

Design outcomes

Primary

Measure	Time frame
The primary endpoint of the trial is the difference in activation of the occipital visual cortex area responsible motion detection (V5/MT) during global visual stimulation after Modafinil and placebo	—

Secondary

Measure	Time frame
Sleep latency (measured by the OSLER test), driving simulator performance and tracking error will be secondary endpoints	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026