Rheumatoid Arthritis Musculoskeletal Diseases Rheumatoid arthritis, unspecified
Conditions
Interventions
The intervention will be of a nutritional supplement: creatine. Participants will be randomly assigned to either a Cr or placebo supplementation group.
12 week oral Cr supplementation with a subseque
Sponsors
Bangor University (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All volunteers have to: 1. Fulfill the American Rheumatism Association 1987 revised criteria for the diagnosis of RA 2. Be functional class I or II 3. Be age 18 years or over, either sex
Exclusion criteria
Exclusion criteria: All volunteers must not: 1. Be cognitively impaired 2. Have any other cachectic diseases and any condition preventing safe participation in the study 3. Have a glomerular filtration rate above 60mL/min/1.73m2, assessed from medical records, and no other evidence of kidney damage 4. Be taking drugs or other nutritional supplements known to increase muscle mass 5. Be participating in regular and intense physical training program 6. Be pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objectively assessed whole body function - measured via the objective physical functional tests at Baseline, Day 6. Week 12 and Week 24 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Body composition - measured via Dual-energy X-ray absorptiometry (DEXA) scan at all time points - Baseline, Day 6. Week 12 and Week 24 2. Muscle strength - measured via the objective physical functional tests at Baseline, Day 6. Week 12 and Week 24 3. Muscle biochemistry - analysed from fasting blood samples taken at Baseline, Week 12 and Week 24. Also analysed from muscle biopsy's (if consented) taken at Baseline and Week 12. | — |
Countries
United Kingdom
Outcome results
None listed