Predicting fluid responsiveness using the mini fluid challenge and pulse contour cardiac output measurements

Predicting fluid responsiveness using the mini fluid challenge and pulse contour cardiac output measurements : a prospective interventional study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37554354

Enrollment

Registered

2015-08-04

Start date

2006-05-01

Completion date

Unknown

Last updated

2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative mechanically ventilated cardiac surgery patients Circulatory System

Interventions

In each patient, a total of 10 consecutive 50 mL fluid boluses with hydroxyethyl starch solution were administered intravenously. Basic heamodynamic maesurements and cardiac output (CO) were registere

modified ModelflowR (COm, FMS, Amsterdam, the Netherlands) and PulseCOR (COli from LiDCO Ltd., London, UK).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing elective coronary artery bypass grafting or valve repair

Exclusion criteria

Exclusion criteria: 1. Previous myocardial infarction 2. Congestive heart failure 3. Aortic aneurysm 4. Extensive peripheral arterial occlusive disease 5. Postoperative valvular insufficiency 6. Artificial pacing and use of a cardiac assist device

Design outcomes

Primary

Measure	Time frame
The area under the curve, positive and negative predictive value of COm and COli for the prediction of fluid responsiveness.	—

Secondary

Measure	Time frame
Predictive capabilities of mini fluid challenges from 50 to 500 ml.	—

Countries

Netherlands, Netherlands Antilles

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026