Intravesical hyaluronic acid (HA) and chondroitin sulphate (CS) for treatment of signs and symptoms of patients with late radiation tissue cystitis (LRTC): an investigative pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37534393

Enrollment

Registered

2013-03-20

Start date

2010-05-01

Completion date

Unknown

Last updated

2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Late radiation tissue cystitis with or without haematuria Urological and Genital Diseases Irradiation cystitis

Interventions

Enrolled patients were treated with intravesical instillations of Ialuril®, a 50 ml/vial solution containing HA 800 mg and CS 1 mg. Patients with severe haematuria (daily) received instillations 5 day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eligible patients with symptomatic LRTC after receiving primary or adjuvant radiotherapy for pelvic neoplasms

Exclusion criteria

Exclusion criteria: 1. Patients (male and female, age range: 40-80 years) undergoing chemotherapy 2. Those with a life expectancy of less than 24 months 3. Those with radiological confirmed metastasis 4. Patients receiving radiotherapy for bladder cancer 5. Patients with documented urethral strictures

Design outcomes

Primary

Measure	Time frame
The tolerability, safety and efficacy of the treatment at reducing the symptoms and signs of LRTC at 3 and 12 months	—

Secondary

Measure	Time frame
Quality of Life (QoL), measured at 3 and 12 months	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 8, 2026