Can brachial artery peak velocity variation and changes in this parameter in response to passive leg raising be used as a marker to predict fluid responsiveness in spontaneously breathing septic patients?

Can brachial artery peak velocity variation and changes in this parameter in response to passive leg raising be used as a marker to predict fluid responsiveness in spontaneously breathing septic patients? ? a non-randomised pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN37255045

Enrollment

Registered

2012-05-08

Start date

2012-04-03

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, spontaneously breathing patients Infections and Infestations Other sepsis

Interventions

1. Passive leg raising (PLR): using the control mechanism on the patient?s bed the trunk will be lowered to the horizontal position and legs raised between 30 and 45 degrees to the trunk. A set of mea

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults (over 18 years old) 2. Sepsis (International Sepsis Definitions Conference); confirmed presence of infectious process plus two or more: 2.1. Body temperature 38.0ºC 2.2. Heart rate > 90 beats per minute 2.3. Respiratory rate > 20 breaths per minute / hyperventilation with a PaCO2 12,000/mm3 or >10% immature neutrophils 3. Arterial line in place 4. Clinical need for fluid: one or more 5. Systolic blood pressure 50mmHg in previously hypertensive patients) or need for vasopressor drugs 6. Presence of oliguria (urine output 2 seconds) 9. Presence of skin mottling

Exclusion criteria

Exclusion criteria: 1. No consent 2. Objection from someone close who is willing to be consulted about the appropriateness of the patient who lacks mental capacity being enrolled in the study in line with the Mental Capacity Act 3. Under 18 years old 4. Pregnant 5. Mechanically ventilated 6. Evidence of fluid overload or pulmonary oedema 7. Allergy to Gelofusin 8. Unable to perform PLR (e.g. pelvic fracture) 9. Exclusion criteria after patients have already been enrolled in the study 9.1. Retrospective withdrawal of consent 9.2. Changes in vasopressor/inotropic requirements during the measurements 9.3. Changes in cardiac rhythm during the measurements

Design outcomes

Primary

Measure	Time frame
Can brachial artery peak velocity variation (BAPVV) at baseline or changes in BAPVV in response to passive leg raising predict fluid responsiveness	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026