Pre-eclampsia Pregnancy and Childbirth Pre-eclampsia
Conditions
Interventions
Women were assigned randomly to receive:
1. Calcium-containing tablets (1.5 g/d), one tablet three times daily (at meal time, greater than 3 hours after any iron supplements)
Sponsors
UNDP/UNFPA/WHO/World Bank - Special Programme of Research, Development and Research Training in Human Reproduction
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Nulliparous pregnant women less than 20 weeks gestation 2. Living in low calcium intake areas
Exclusion criteria
Exclusion criteria: 1. The presence of blood pressure greater than 140 and/or 90 mmHg at first antenatal visit 2. A history of chronic hypertension or renal disease 3. A history or signs and/or symptoms of nephrolithiasis, parathyroid disorders, and diseases that require digoxin, phenytoin, or tetracycline therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Primary maternal outcome: incidence of preeclampsia and/or eclampsia 2. Primary neonatal outcome: preterm delivery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Early preterm delivery (less than 32 weeks of gestation) 2. Term low birth weight (less than 2500 g; greater than or equal to 37 weeks of gestation) 3. Hospitalisation of greater than 2 days 4. Greater than or equal to 7 days in the neonatal intensive care unit 5. Foetal, neonatal, and perinatal death | — |
Countries
Argentina, Egypt, India, Peru, South Africa, Switzerland, Viet Nam
Outcome results
None listed