Prehospital recognition and antibiotics for 999 patients with severe sepsis

Conditions

Sepsis Infections and Infestations Sepsis, unspecified

Jenna Jones, Susan Allen, Jan Davies, Timothy Driscoll, Gemma Ellis et al. (21 authors)

Scientific Reports2021-09-2011 citations

Prehospital recognition and antibiotics for 999 patients with sepsis: protocol for a feasibility study.

Moore C, Bulger J, Morgan M, Driscoll T, Porter A, Islam S, Smyth M, Perkins G, Sewell B, Rainer T, Nanayakkara P, Okolie C, Allen S, Fegan G, Davies J, Foster T, Francis N, Smith FG, Ellis G, Shanahan T, Howe R, Snooks H.

2018-03-127 citations

10.1186/s40814-018-0258-8

Interventions

Sixty paramedics will be recruited to the study and will receive an enhanced level of training to assist them to recognise severe sepsis. If severe 'Red Flag’ sepsis is suspected, paramedics will sele

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients 18 years of age and above 2. Attended by study paramedics 3. Identified as 'Red Flag’ sepsis 4. Admitted to participating hospital

Exclusion criteria

Exclusion criteria: 1. Pregnancy (known or suspected) 2. Known history of allergy to antibiotics

Design outcomes

Primary

Measure	Time frame
The feasibility of undertaking a randomised controlled trial (RCT) to test the clinical and cost-effectiveness of paramedics providing IV antibiotics as early treatment for patients with severe sepsis. The trialists will assess whether or not to proceed to a full multi-site RCT based on the following progression criteria: 1. 60% of the 100 eligible paramedics agree to take part in the study 2. 70% of eligible patients consent to take part in the study 3. Follow-up data for potential primary outcomes can be collected for 70% or more of patients at 90 days 4. Mean patient satisfaction in intervention group is not less than 80% of patient satisfaction in the control group 5. Feasibility trial findings indicate that they remain in equipoise about the effectiveness of paramedic collection of blood cultures and antibiotic administration (i.e. that delivery of the intervention does not exceed a greater than 20-minute difference in on-scene times for patients compared to those in the control group) 6. Adverse event rate (e.g. allergic (anaphylactic) reactions to antibiotics) of less than 5%	—

Measure

Time frame

The feasibility of undertaking a randomised controlled trial (RCT) to test the clinical and cost-effectiveness of paramedics providing IV antibiotics as early treatment for patients with severe sepsis. The trialists will assess whether or not to proceed to a full multi-site RCT based on the following progression criteria: 1. 60% of the 100 eligible paramedics agree to take part in the study 2. 70% of eligible patients consent to take part in the study 3. Follow-up data for potential primary outcomes can be collected for 70% or more of patients at 90 days 4. Mean patient satisfaction in intervention group is not less than 80% of patient satisfaction in the control group 5. Feasibility trial findings indicate that they remain in equipoise about the effectiveness of paramedic collection of blood cultures and antibiotic administration (i.e. that delivery of the intervention does not exceed a greater than 20-minute difference in on-scene times for patients compared to those in the control group) 6. Adverse event rate (e.g. allergic (anaphylactic) reactions to antibiotics) of less than 5%

—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom, Wales

Contacts

Public ContactJenna Bulger

j.k.bulger@swansea.ac.uk+44 (0)179 251 3424

Outcome results

None listed