Spinal cord stimulation for the treatment of central pain in Multiple Sclerosis

Comparison of spinal cord stimulation and the clinical and quantitative sensory testing response in patients with MS pain versus patients with peripheral nerve injury pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN36818685

Enrollment

Registered

2010-04-23

Start date

2008-07-01

Completion date

Unknown

Last updated

2018-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Neurological

Interventions

Trial of spinal cord stimulation. A temporary electrode is inserted into the eipdural space and attached to an external radiofrequency transmitter, which when switched on gives a pleasant paraesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Group 1: Confirmed MS with central pain 2. Group 2: Peripheral nerve injury pain 3. Both groups eligible for spinal cord stimulation 4. Group 3: Age- and gender-matched healthy controls 5. Male and female, aged 18 years or older

Exclusion criteria

Exclusion criteria: 1. Unsuitable for spinal cord stimulation 2. High intake of opiates 3. High levels of psychological distress

Design outcomes

Primary

Measure	Time frame
Changes in pain scores measured by daily pain diaries, measured on day 7 of the trial	—

Secondary

Measure	Time frame
Comparison of QST measurements in MS patients with and without stimulation, measured on day 5 of the trial, when the second sensory testing is complete	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026