Cardiac functions in patients with early-phase septic shock Signs and Symptoms Septic shock
Conditions
Interventions
Subjects are randomly assigned to three groups:
1. The Ns group: patients are injected with 5 ml/kg of normal solution (n = 30)
2. The Hs group (n=30), patients are injected with 5 ml/kg of 3.5% sodiu
Sponsors
The Second Hospital of Nanjing, affiliated with Medical College, Southeast University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patents with early phase septic shock (according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine). The criteria for inclusion is fulfilment of two out of the four criteria for the systemic inflammatory response syndrome (SIRS) and a systolic blood pressure lower than 90 mmHg or a reduction of 40 mm Hg from baseline.
Exclusion criteria
Exclusion criteria: Patients with a myocardial infarction, hemorrhagic shock, trauma, pregnancy, do-not-attempt-resuscitation orders, or immediate surgery requirement are excluded. In order to focus the study on the subject of early phase septic shock, the patients with last-phase septic shock characterized by coma, seizure, diffusing intravascular coagulation (DIC), pulmonary edema and anuria on admission were rejected. The cases treated with vasopressors, inotropic agents and mechanical ventilation during the initial two hours or with death imminent within 24 hours were also rejected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac output (CO) and mean arterial pressure during 8 hours after starting fluid treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Respiratory rate, heart rate and temperature 2. Blood gas and electrolyte 3. 28-day mortality | — |
Countries
China
Outcome results
None listed