The Zambia, South Africa, Tuberculosis and Acquired Immune Deficiency Syndrome-reduction Trial

Conditions

Tuberculosis Infections and Infestations Tuberculosis

Emma Murray, Peter J. Dodd, Ben J. Marais, Helen Ayles, Kwame Shanaube et al. (8 authors)

BMJ Open2021-12-015 citations

10.1136/bmjopen-2020-047136

Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial.

Ayles H, Muyoyeta M, Du Toit E, Schaap A, Floyd S, Simwinga M, Shanaube K, Chishinga N, Bond V, Dunbar R, De Haas P, James A, Gey van Pittius NC, Claassens M, Fielding K, Fenty J, Sismanidis C, Hayes RJ, Beyers N, Godfrey-Faussett P, ZAMSTAR team.

2013-08-01189 citations

10.1016/s0140-6736(13)61131-9

ZAMSTAR, The Zambia South Africa TB and HIV Reduction Study: design of a 2 x 2 factorial community randomized trial.

Ayles HM, Sismanidis C, Beyers N, Hayes RJ, Godfrey-Faussett P.

2008-11-0754 citations

10.1186/1745-6215-9-63

Interventions

The two interventions are: 1. Improved case finding: by allowing individuals direct access to diagnostic services and empowering communities to seek care, we will bypass the health system barriers and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Population served by tuberculosis diagnostic centre in each of 24 communities

Exclusion criteria

Exclusion criteria: Individuals who do not consent to trial procedures

Design outcomes

Primary

Measure	Time frame
The primary outcome will be the prevalence of culture-positive tuberculosis among a randomly selected population of adults in each arm of the trial, measured after 3 years of the interventions	—

Secondary

Measure	Time frame
Secondary outcomes measured at the community level include: 1. Cumulative incidence of tuberculosis infection in school children 2. Indicators of tuberculosis and HIV programme performance At the household level, they include: 1. Cumulative incidence of tuberculosis 2. Changes in HIV incidence and stigma	—

Countries

England, South Africa, United Kingdom, Zambia

Outcome results

None listed