Placental vascular flow Pregnancy and Childbirth
Conditions
Interventions
Once the patients have been properly advised about the study and the consent form has been signed as a part of their agreement, patients are sent to the hospital to undergo an initial ultrasound exam
Sponsors
Servicio Ginecologia y Obstetricia Hospital General de Valencia
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy women between 20-40 years old 2. Confirmed pregnant viability without any obstetric complication 3. First trimester gestational age 4. Coming to hospital for legal medical abortion
Exclusion criteria
Exclusion criteria: 1. Obstetric risk factors: recurrent miscarriage, previous preeclamsia and hematology disease 2. Current use of vasoactive drugs (mainly related to hypertension treatment) 3. Toxic substances abuse 4. Threatened abortion symptoms 5. Sildenafil citrate contraindications, as are described in the prescribing information formulary (excluding pregnancy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Placental vascular flow, measured by standard vascular indexes acquired with three dimensional angiopower doppler output when the patient is admitted and one hour later (following drug or placebo administration) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Uterine artery hemodynamic flow effect, measured using an automated semiquantitative analysis of Doppler spectra before and 1 hour after Sildenafil oral administration 2. Maternal blood pressure, measured using an automated oscillometric blood pressure measurement device before and during one hour (every 15 minutes) after Sildenafil oral administration 3. Maternal heart frequency, calculated automatically using waveform spectra before and 1 hour after Sildenafil oral administration | — |
Countries
Spain
Outcome results
None listed