Tuberculosis Infections and Infestations Respiratory tuberculosis, not confirmed bacteriologically or histologically
Conditions
Interventions
Patients were randomised in blocks to receive:
1. Anti-TB routine treatment plus 90 mg elementary zinc weekly (as zinc sulphate in a lactose matrix in form of a tablet) plus a placebo
Sponsors
Zankli Medical Centre (Nigeria)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Willingness to take part in the study 2. Newly diagnosed as having active PTB as per the World Health Organization (WHO) definition of smear positive TB 3. Aged 15 years and above, either sex 4. Should not have a history of anti-TB treatment
Exclusion criteria
Exclusion criteria: 1. Moderate to severe surgery during the previous month 2. History of diabetes mellitus or severe cardiovascular, liver or renal diease 3. Previous treatment for TB 4. Taking corticosteroids, zinc or vitamin A supplementation during the previous month 5. Pregnant, lactating or taking oral contraceptives 6. Patient could not attend follow up visits regularly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To determine the time to sputum clearance of bacilli (proportion of TB bacilli cleared from sputum at enrolment, 2nd and 6th month, using smear microscopy in the three groups) 2. To determine the resolution of lesion areas in chest x-rays in the three groups at enrolment, 2nd and 6th month | — |
Secondary
| Measure | Time frame |
|---|---|
| To look at the clinical and laboratory differences between the three groups at enrolment, 2nd and 6th month. | — |
Countries
Nigeria
Outcome results
None listed