Evaluation of the effects of azithromycin and platelet-rich fibrin on wound healing after surgical removal of mandibular third molars

Cytomorphometric, immunological, and clinical analysis of the effects of azithromycin and platelet-rich fibrin on postoperative wound healing following surgical extraction of impacted mandibular third molars

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN36568405

Enrollment

Registered

2026-05-22

Start date

2024-04-03

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical extraction of impacted mandibular third molar Oral Health

Interventions

Participants were randomly allocated into three study groups using computer-generated randomisation. Group assignments were placed in sequentially numbered, sealed opaque envelopes, which were opened

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Vertically impacted third molars that are radiographically diagnosed according to Winter’s classification

Exclusion criteria

Exclusion criteria: 1. Allergies to penicillin or lidocaine 2. Chronic systemic diseases 3. Cystic lesions 4. Infections around the impacted third molar, odontomas, or syndromes affecting the orofacial region

Design outcomes

Primary

Measure	Time frame
Cytomorphometric changes (area, IntDen, AR, StdDev, Min, Max, Perim, Circ, FeretX, FeretY, and roundness) measured using exfoliative cytology with Papanicolaou staining and ImageJ morphometric analysis at baseline and postoperative day 7;Immunologic observation in cervical fluid samples measured using an ELISA at preoperative and postoperative;Microbiological findings measured using PCR analysis at preoperative and postoperative	—

Measure

Time frame

Cytomorphometric changes (area, IntDen, AR, StdDev, Min, Max, Perim, Circ, FeretX, FeretY, and roundness) measured using exfoliative cytology with Papanicolaou staining and ImageJ morphometric analysis at baseline and postoperative day 7;Immunologic observation in cervical fluid samples measured using an ELISA at preoperative and postoperative;Microbiological findings measured using PCR analysis at preoperative and postoperative

—

Secondary

Measure	Time frame
Postoperative pain measured using a Visual Analogue Scale (VAS) at postoperative days 3 and 7;Postoperative edema, assessed via standardized facial reference point distances (tragus–gonion and tragus–oral commissure) measured using manual linear measurements with a flexible measuring tape at baseline and postoperative day 7;Wound healing measured using the Landry Healing Index at postoperative days 3, 7, and 14	—

Measure

Time frame

Postoperative pain measured using a Visual Analogue Scale (VAS) at postoperative days 3 and 7;Postoperative edema, assessed via standardized facial reference point distances (tragus–gonion and tragus–oral commissure) measured using manual linear measurements with a flexible measuring tape at baseline and postoperative day 7;Wound healing measured using the Landry Healing Index at postoperative days 3, 7, and 14

—

Countries

Serbia

Contacts

Public ContactSimona Stojanovic

simona.stojanovic@medfak.ac.rs+381692245322

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026