Abnormal heart rhythms Circulatory System
Conditions
Interventions
Participants undergoing CRT- D implant will either be randomised to have the pacemaker set at the conventional method of pacing the left side of the heart from one location (MPP off) or will have the
Sponsors
Guy's and St Thomas' NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Scheduled to undergo an implant of a CRT-D system with approved standard indication by ESC/EHRA guidelines 2. Ability to provide informed consent for study participation and be willing to comply with the enrolment and follow up evaluations 3. Aged 18 years and over
Exclusion criteria
Exclusion criteria: 1. Recent myocardial infarction within 40 days prior to enrolment 2. Cardiac surgery or coronary revascularisation procedure within 3 months prior to enrolment or be scheduled for such procedures in the following 7 months 3. Intravenous inotropic support within the last 30 days 4. Under 18 years of age 5. Be pregnant or plan to become pregnant over the next 7 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of left ventricular reverse remodelling is measured using LV volume reduction at 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the incidence of treated ventricular arrhythmias is measured by the number of incidents reported over the duration of the 2 years participant is in the study. | — |
Countries
United Kingdom
Contacts
Public ContactMatthew Osmond
Outcome results
None listed