Exercise Training in Chronic Kidney Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN36489137

Enrollment

Registered

2014-02-21

Start date

2013-12-02

Completion date

Unknown

Last updated

2019-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease Urological and Genital Diseases Chronic kidney disease

Interventions

Randomised study of supervised cardiovascular exercise versus supervised cardiovascular plus resistance exercise, with a 6 week usual activity run-in period for all participants. 12 w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and female aged between 18 and 100 years 2. Established Chronic kidney disease (Stages 3b-5) 3. Attending Nephrology outpatient clinics in the Leicester region

Exclusion criteria

Exclusion criteria: 1. Age 9%), advanced cerebral or peripheral vascular disease) 3. Insufficient command of English to give informed consent or comply with the testing and training protocol. If the results indicate that the intervention is useful, future larger studies will include provision for those whose first language is not English. 4. BMI> 40 with waist circumference >102cm for males and >88 for females. Two measures of obesity have been included here to allow for the inclusion of individuals with a high BMI due to a larger muscle mass, as BMI is unable to discriminate between fat mass and fat free mass.

Design outcomes

Primary

Measure	Time frame
Muscle strength (total weight lifted during training sessions and estimated 1 repetition maximum of quadriceps extension) measured at 6 weeks, 12 weeks, 18 weeks	—

Secondary

Measure	Time frame
1. Quadriceps Muscle size: Magnetic Resonance Imaging & 3D Ultrasonography. Measured at baseline, 6 weeks, 18 weeks 2. Exercise Capacity: VO2peak. Measured at baseline, 6 weeks, 18 weeks 3. Physical Function: Shuttle walk tests; sit to stand tests. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 4. Daily Physical Activity: 7 day Accelerometry. Measured at baseline, 6 weeks, 18 weeks 5. Body composition: Weight, height, waist circumference. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 6. Arterial Stiffness: Pulse Wave Velocity. Measured at baseline, 6 weeks, 18 weeks 7. Clinical parameters: Extracted from medical records. Measured at baseline, 6 weeks, 18 weeks 8. Muscle metabolism: Muscle biopsy. Measured at 6 weeks, 18 weeks 9. Plasma markers of inflammation and oxidative stress, Venous blood sample. Measured at baseline, 6 weeks, 18 weeks 10. Quality of Life: SF36 and EQ5D questionnaires. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 11. Symptom perception: Chronic Kidney Disease Symptom Score. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 12. Physical Activity habits and attitudes: Leicester Kidney Patient Physical Activity Questionnaire (comprising Duke Activity Status Index; GP Physical Activity Questionnaire; Leisure Time Exercise Questionnaire; Stage of Change Questionnaire; Self Efficacy Questionnaire). Measured at baseline, 6 weeks, 12 weeks, 18 weeks 13. Fatigue: FACIT-Fatigue Questionniare & Visual Analogue Scale. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 14. Appetite: Visual Analogue Scale. Measured at baseline, 6 weeks, 12 weeks, 18 weeks	—

Measure

Time frame

1. Quadriceps Muscle size: Magnetic Resonance Imaging & 3D Ultrasonography. Measured at baseline, 6 weeks, 18 weeks 2. Exercise Capacity: VO2peak. Measured at baseline, 6 weeks, 18 weeks 3. Physical Function: Shuttle walk tests; sit to stand tests. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 4. Daily Physical Activity: 7 day Accelerometry. Measured at baseline, 6 weeks, 18 weeks 5. Body composition: Weight, height, waist circumference. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 6. Arterial Stiffness: Pulse Wave Velocity. Measured at baseline, 6 weeks, 18 weeks 7. Clinical parameters: Extracted from medical records. Measured at baseline, 6 weeks, 18 weeks 8. Muscle metabolism: Muscle biopsy. Measured at 6 weeks, 18 weeks 9. Plasma markers of inflammation and oxidative stress, Venous blood sample. Measured at baseline, 6 weeks, 18 weeks 10. Quality of Life: SF36 and EQ5D questionnaires. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 11. Symptom perception: Chronic Kidney Disease Symptom Score. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 12. Physical Activity habits and attitudes: Leicester Kidney Patient Physical Activity Questionnaire (comprising Duke Activity Status Index; GP Physical Activity Questionnaire; Leisure Time Exercise Questionnaire; Stage of Change Questionnaire; Self Efficacy Questionnaire). Measured at baseline, 6 weeks, 12 weeks, 18 weeks 13. Fatigue: FACIT-Fatigue Questionniare & Visual Analogue Scale. Measured at baseline, 6 weeks, 12 weeks, 18 weeks 14. Appetite: Visual Analogue Scale. Measured at baseline, 6 weeks, 12 weeks, 18 weeks

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026