Pyelonephritis Urological and Genital Diseases Pyelonephritis
Conditions
Interventions
MR-imaging is performed within 8 hours of the DMSA scan. MR examinations of the abdomen and pelvis are performed with the patient in supine position and with a body phased-array coil (better signal-to
Sponsors
Foreest Medical School (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients from 0 to 18 years, with: 1.1. Acute pyelonephritis, defined as a urinary tract infection (UTI) with a body temperature above 38 °C 1.2. Suspicion of acute pyelonephritis, suggested by symptoms of a UTI and flank pain 2. For young children (under the age of 1 year and in the pre-verbal phase) other clinical symptoms can suggest pyelonephritis. This is bacteriuria with either fever, vomitus, lethargia, anorexia, abdominal pain, pollakisuria or flank pain 3. Outside the study setting, the patient would have received a dimercaptosuccinic acid (DMSA) scan 4. Patients, or a legal representative, must be able to give informed consent, and the consent must be obtained prior to the MR Imaging and DMSA scanning
Exclusion criteria
Exclusion criteria: 1. Previous diagnosis of pyelonephritis 2. All contra-indications for undergoing MRI 3. A psychiatric, addictive, or any disorder that compromises the ability to give truly informed consent for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The sensitivity, specificity, positive and negative predictive value and inter observer agreement of MRI in diagnosing acute pyelonephritis as compared to the reference standard. 1.1. The MRI findings will be compared to the findings at imaging of the standard diagnostic work-up that preceded MRI. The diagnostic value of specific MRI characteristics for pyelonephritis will be calculated. The value of diffusion-weighted imaging (DWI) will be analysed. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine whether MR-diffusion weighted imaging (DWI) has additional value in the imaging of pyelonephritis 2. To determine whether MRI scanning can differentiate acute pyelonephritis from renal scarring | — |
Countries
Netherlands
Outcome results
None listed