The effect of antibacterial photothermal therapy on plaque in healthy adults

Indocyanine green-mediated antibacterial photothermal therapy in the development of plaque in healthy adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN36318197

Enrollment

Registered

2020-09-02

Start date

2017-04-01

Completion date

Unknown

Last updated

2021-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infective dental diseases, mainly periodontitis and caries Oral Health

Interventions

The treatment period comprises four treatment sessions within four consecutive days, and the treatment itself consists of a light applicator and the ICG photoactive substance. Medications that could a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Generally healthy 2. Age between 18 to 65 3. Ability to refrain from brushing one's teeth during the treatment period 4. Informed consent given

Exclusion criteria

Exclusion criteria: 1. Diabetes 2. Medications that may affect the immune response or saliva secretion 3. Malignancy 4. Pregnancy 5. Dental implants or prosthesis 6. Fixed orthodontic appliances 7. An active or a chronic oral infection

Design outcomes

Primary

Measure	Time frame
Change in the plaque area after the treatment period in treated and untreated teeth, measured using indocyanine green and photography under near-infrared lighting and white light lighting conditions; images taken daily during the 4-day study period	—

Secondary

Measure	Time frame
1. The amount of plaque measured as an area on the dental surface, measured using indocyanine green and photography under near-infrared lighting and white light lighting conditions (images taken daily during the 4-day study period) 2. The percentage of plaque area of the selected dental surface area, measured using indocyanine green and photography under near-infrared lighting and white light lighting conditions (images taken daily during the 4-day study period) 3. Amount of MMP-8 in gingival crevicular fluid by a time-resolved immunofluorescence assay pre-and post-intervention (samples taken daily during the 4-day study period) 4. 16S bacteriological ecology pre- and post-intervention: V3-V4 regions of the 16S rRNA genes amplified and sequenced with an Illumina MiSeq sequencer (San Diego, CA, USA) (samples taken at day 0 (preintervention) and at day 4 (postintervention) of the study)	—

Measure

Time frame

1. The amount of plaque measured as an area on the dental surface, measured using indocyanine green and photography under near-infrared lighting and white light lighting conditions (images taken daily during the 4-day study period) 2. The percentage of plaque area of the selected dental surface area, measured using indocyanine green and photography under near-infrared lighting and white light lighting conditions (images taken daily during the 4-day study period) 3. Amount of MMP-8 in gingival crevicular fluid by a time-resolved immunofluorescence assay pre-and post-intervention (samples taken daily during the 4-day study period) 4. 16S bacteriological ecology pre- and post-intervention: V3-V4 regions of the 16S rRNA genes amplified and sequenced with an Illumina MiSeq sequencer (San Diego, CA, USA) (samples taken at day 0 (preintervention) and at day 4 (postintervention) of the study)

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Countries

Finland

Contacts

Public ContactTommi Pätilä

tommi.patila@gmail.com+358 (0)440130770

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026