Sepsis and adrenal insufficiencies Infections and Infestations Sepsis and adrenal insufficiencies
Conditions
Interventions
Patients enrolled in the study were treated with standard therapy used in the treatment of sepsis and septic shock. This therapy could include administration of antibiotics, fluid replacement, vasoact
Sponsors
Erciyes University (Turkey)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients over 17 years old and diagnosed with sepsis were included in the study consecutively. The diagnosis of sepsis was based on the definition of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Report. The severity of illness was classified according to this definition.
Exclusion criteria
Exclusion criteria: Criteria for exclusion from the study were as follows: 1. Already known pre-existing adrenal disease or adrenalectomy 2. Known malignancies, tuberculosis that might have involved the adrenal gland 3. Administration of steroids within the three months before the admission 4. In addition, patients with burns, hemorrhagic shock or those who had suffered myocardial infarction were not included
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study was 28-day mortality from all causes. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint consisted of adverse occurrences including possible complications of drug therapy and morbid events such as the progression of initial infection and the development of secondary infection. Secondary infection was defined as the identification of a new site of infection or the emergence of a different organism at the same site, generally requiring a change in antibiotic management. | — |
Countries
Turkey
Outcome results
None listed