Periodontitis, cardiovascular diseases, metabolic syndrome Oral Health
Conditions
Interventions
1. Scaling and root planing alone
2. Scaling and root planing + amoxicillin 375mg + metronidazole 250mg
3. Scaling and root planing + subgingival irrigation with 0.5% N
Sponsors
Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrij University of Amsterdam (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients both males and females, being 20 years or older 2. Patients affected by periodontitis defined as presence of 1/3 bone loss or more and presence of 6 mm pocket or more, with evidence of attachment loss at 2 or more teeth per quadrant and evidence of generalized bleeding
Exclusion criteria
Exclusion criteria: 1. No systemic chronic diseases 2. No acute medical interventions or diseases 4 weeks before baseline 3. No pregnancy 4. No chronic medications 5. No antibiotics 6 months before intake and no repeated use of NSAID's medications 4 weeks before intake 6. No hypersensitivity of contraindication for the use of amoxicillin and metronidazole
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Markers of cardiovascular diseases and metabolic syndrome in peripheral plasma and serum (hsCRP, Lipid profile, hemostatic factors, glucose, insuline, HbA1c). Measured at baseline (before treatment), 3 months, 6 months and 12 months after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical (probing pocket depth, bleeding index, plaque index, attachment level) and microbiological parameters of periodontitis. Measured at baseline (before treatment), 3 months, 6 months and 12 months after treatment. | — |
Countries
Netherlands
Outcome results
None listed