Short term effects of high polyphenol content chocolate on blood vessel health

High polyphenol chocolate effects on endothelial reactivity acutely in type 2 diabetes: a double-blind placebo controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35988358

Enrollment

Registered

2009-09-22

Start date

2009-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes Nutritional, Metabolic, Endocrine Non-insulin-dependent diabetes mellitus

Interventions

Pre-loading subjects with water with 13.5 g chocolate with or without polyphenols prior to oral glucose tolerance test.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male or post menopausal female, aged between 40-75 2. Type 2 diabetes 3. Managed with diet or exercise alone or metformin 4. Stable medication

Exclusion criteria

Exclusion criteria: 1. Unwilling to allow contact with GP 2. Diabetes treated with other agents

Design outcomes

Primary

Measure	Time frame
Improved endothelial function as measured by EndoPAT™. Endothelial function was assessed before consumption of the chocolate, then at 60 and 180 min following consumption of the chocolate.	—

Secondary

Measure	Time frame
1. Insulin response 2. C-reactive protein (CRP) The secondary outcomes were measured before consumption of the chocolate, then every 30 min until 180 min after consumption of the chocolate.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026