Surgery: Cardiovascular Surgery Cardiovascular
Conditions
Interventions
Patients under the care of the Cambridge Vascular Unit undergoing femoro-popliteal angioplasty or femoro-popliteal/tibial bypass will be eligible for the study. The indication for intervention will be
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Eligibility
Inclusion criteria
Inclusion criteria: Serum samples collected at the time of vascular intervention (radiologist or surgeon). Follow up samples by vascular research fellow. Arterial wall and vein biopsies taken at the time of surgery by operating surgeon.
Exclusion criteria
Exclusion criteria: 1. Patient unable to give informed consent 2. Age < 18 years 3. Pregnancy, planned pregnancy 4. Life expectancy less than 12 months 5. Inability to monitor the angioplasty site or graft with ultrasound for stenosis 6. Unable to take SDD (ie allergic reaction) or currently taking tetracyclines 7. Unable to take adjuvant treatment with antiplatelet/anticoagulant agent and statin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. MMP activities SDD versus placebo 2. CRP levels 3. Endothelial function and re-stenosis 4. Arterial wall stiffness and re-stenosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed